한국콩연구회

노화로 전립선기능이 감소한 환자에서 검정콩 종피추출물이 기능개선에 미치는 영향 : 기능성원료개발

The effect of anthocyanin extracted from black soybean to improve prostate health in patients with decreased prostate function due to aging

사업명 : 차세대바이오그린21

주관연구기관 : 가톨릭대학교

연구책임자 : 김세웅

발행년월 : 2015-02

주관부처 : 농촌진흥청

원문

http://www.ndsl.kr/ndsl/commons/util/ndslOriginalView.do?dbt=TRKO&cn=TRKO201500010710&rn=&url=&pageCode=PG18

초록

Benign prostate hyperplasia has been shown to have a high incidence in elderly males and affects their quality of life. In previous report, the oxidative stress mechanism is related to the occurrence and progression of BPH and anthocyanin is a potent antioxidant that can decrease prostate volume and prevent BPH progression. Therefore, we should evaluate whether anthocyanins extracted from black soybean have beneficial effect on low urinary tract symptoms in men. Administration of black soybean to animals during induction of BPH resulted in a reduction in prostate weight, oxidative stress, and 5-alpha reductase activity, as well as a decrease in apoptosis. We demonstrated that anthocyanins extracted from black soybean have lowered IPSS in men with low urinary symptoms through clinical trials. So we suggest that the antioxidant properties and inhibitory effect of 5-alpha reductase of isoflavones and anthocyanin would be effective in treating BPH. Based on this results , innovative treatment for benign prostate hyperplasia can be commercialized.

연구개발 결과

○ 전립선 기능 저하 동물모델에서 검정콩 추출물을 투여하여 전립선 무게의 감소 및 전립선 조직 증식 억제를 확인함

○ 인체적용시험에서 위약군 대비 약물 투여군에서 국제전립선증상점수의 개선을 확인함

○ 이러한 치료효과는 세포 고사 및 5알파 환원효소 억제가 주기전임을 확인하였으며 검정콩의 주성분 인 안토시아닌과 이소플라본이 그 역할을 한 것으로 기대함