한국콩연구회

전통적인 식품 소재 콩을 이용한 항당뇨 물질 개발 및 산업화

Industrialization and Development of anti-hyperglycemic food material from soybean hydrolysate using enzymatic system

사업명 : 고부가가치식품기술개발

주관연구기관 : 대구대학교

연구책임자 : 최장원

발행년월 : 2012-04

주관부처 : 농림축산식품부

원문

http://www.ndsl.kr/ndsl/commons/util/ndslOriginalView.do?dbt=TRKO&cn=TRKO201400026527&rn=&url=&pageCode=PG18

연구결과

1. 연구논문

본 연구에서 얻어진 직, 간접의 결과들을 이용하여 국내 및 국제 저널에 투고하여 발간하였다.

가. 국내 논문

(1) Choi,J.W. 2011. Anti-diabetic effect of the exopolysaccharide (EPS) produced from Cordyceps sinensis on ob/ob mice. Korean Society for Biotechnology & Bioengineering Journal. 26: 33-40.

(2) Ra, K.S. and J. W. Choi. 2011. Enhancement of cyclo (His-Pro) content from soybean fermented with Bacillus amyloliquefacienc CHP-12 and Its anti-diabetic effect. Korean Society for Biotechnology & Bioengineering Journal. 26: 41-48.

나. 국제논문

(1) Choi, J.W., K.S. Ra, S.Y. Kim, T.J. Yoon, K. W. Yu, K.S. Shin, S.P. Lee, and H.J. Suh. 2010. Enhancement of anti-complementary and radical scavenging activities in the submerged culture of Cordyceps sinensis by addition of cirus peel. Bioresource Technology. 101(15): 6028-6034. (SCI, Impact factor = 4.365)

(2) Jung, E.Y., H.S. Lee, J.W. Choi, K.S. Ra, M. R. Kim, and H.J. Suh. 2011. Glucose tolerance and antioxidant activity of spent brewer's yeast hydrolysate with a high content of cyclo-His-Pro (CHP). J. Food Science. 76(2): C272-C278. (SCI, IF = 1.733)

(3) Koo, K.B., H.J. Suh, K.S. Ra, and J.W. Choi. 2011. Protective effect of cyclo(His-Pro) on streptozotocin-induced cytotoxicity and apoptosis in vitro. J. Microbiol. Biotechnol. 21: 218-227. (SCIE, IF = 1.381)

(4) Ra, K.S., H.J. Suh, and J. W. Choi. 2012. Hypoglycemic effects of cyclo (His-Pro) in streptozotocin-induced diabetic rats. Biotechnology and Bioprocess Engineering. 17: 176-184. (SCIE, IF = 1.278)

(5) Park, S.W., S.A. Choi, J.W. Yun, and J.W. Choi. 2012. Alterations in pancreatic protein expression in STZ-induced diabetic rats and genetically diabetic mice in response to treatment with hypoglycemic dipeptide cyclo (His-Pro). Cellular Physiology and Biochemistry. 29: 603-616. (SCI, IF = 3.585)

(6) Choi, S.A., H.J. Suh, J. W. Yun, and J.W. Choi. 2012. Differential gene expression in pancreatic tissues of streptozocin-induced diabetic rats and genetically-diabetic mice in response to hypoglycemic dipeptide cyclo (His-Pro) treatment. Molecular Biology Reports. 39(8): 8821-8835 (SCI, IF = 2.929)

(7) Choi, S.A., J.W. Yun, H. S. Park, and J.W. Choi. 2013. Hypoglycemic dipeptide cyclo (His-Pro) significantly altered plasma proteome in streptozocin-induced diabetic rats and genetically-diabetic (ob/ob) mice. Molecular Biology Reports. 40(1): 1753-1765 (SCI, IF = 2.929)

2. 특허

가. 바실러스 속 KH-15의 콩 발효물을 유효성분으로 포함하는 당뇨병 예방 및 치료용 조성물 (출원일자 2011.01.07; 출원번호 10-2011-0001900)

나. CHP(cyclo(His-Pro))를 고농도로 함유한 대두 가수분해물을 포함하는 혈당 조절용 조성물 (출원일자 2011.07.08; 출원번호10-2011-0068055)

다. 바실러스 속 KH-15의 콩 발효물을 유효성분으로 포함하는 당뇨병 예방 및 치료용 조성물 (등록일자 : 2013.01.21; 등록번호 :특허 제10-1226548)